Researchers at the University of Adelaide have published the first findings on the potential efficacy of an innovative gene-driven technology to control invasive mice.
The team has developed the world’s first proof-of-concept of this technology, called t-CRISPR, using laboratory mice.
Using advanced computer modeling performed by co-first author Dr. Aysegul Birand, the researchers also found that about 250 genetically modified mice could eradicate an island population of 200,000 mice in about 20 years. did.
The results of this study were published today in the prestigious international journal Proceedings of the National Academy of Sciences, USA.
Professor Paul Thomas, Principal Investigator at the University of Adelaide and the South Australian Institute of Health and Medical Research (SAHMRI) said:
“The t-CRISPR approach uses state-of-the-art DNA editing technology to alter female fertility genes.
“We are also developing new versions of t-CRISPR technology designed to target specific pest populations to prevent the unwanted spread of gene drives.”
Graduate student Luke Gieras, co-first author of the study, said t-CRISPR is the first gene-biological control tool for invasive mammals.
“Previously, this technology was aimed at insects trying to stem the epidemic of malaria, which kills half a million people a year worldwide,” says Gierus.
“Using t-CRISPR technology allows a humane approach to control invasive mice without releasing toxins into the environment. It also prevents eradication failures due to the emergence of gene-driven resistance in target populations.” We are also working on a strategy for
“This is the first time that a new genetic tool has been identified that suppresses invasive mouse populations by inducing female infertility.
Professor Thomas said the research team is working closely with Australia’s National Science Agency CSIRO, the Center for Invasive Species Solutions, the Genetic Biological Control of Invasive Rodents (GBIRd) Consortium, and the United States Department of Agriculture to develop new technologies safely. You said you’ve considered the next steps to implement.
“Our broader project includes consideration of societal views and attitudes and is essential to our ongoing research related to this gene drive,” said Professor Thomas.
Dr. Owain Edwards, CSIRO Group Leader for Environmental Mitigation and Resilience, added:
“As part of this study, we are conducting a safety evaluation of this technology to the highest standards. As this is the first prototype of a vertebrate gene drive, interested stakeholders have many members of the international community. included.”
This research was supported by the South Australian Government and the NSW Government.
Deputy Prime Minister of South Australia, Dr Hon. Susan Crouse MP said:
“This cutting-edge research also highlights the global leadership of South Australia’s research sector in finding solutions to social, environmental and economic challenges.
“The South Australian Government is proud to provide $1 million to the University of Adelaide through its Research and Innovation Fund to support this proof of concept.”
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